A. Do you agree? My experience with Zetia Imagine walking to a friend’s dinner party. Here is another question we got from a reader around that time: Q. I am alarmed by recent reports that Vytorin and Zetia are associated with plaque build-up in the carotid artery. The study was funded by the two companies that make Zetia, Merck and Schering-Plough. Learn about side effects, dosage, and more. We donât know how the benefits and risks of PCSK9 inhibitors will play out over time. When using Zetia, there is an increased possibility of myopathy (any illness affecting muscles or muscle tissue) and you must on time report any muscle pains, weakness, or softness to your doctor. Zetia (ezetimibe) is a lipid -lowering compound used to treat high cholesterol. What Are Side Effects of Zetia? A. However, according to the Mayo Clinic, Zetia does have known side effects, one of which is dysphagia or trouble swallowing. GAUSS-3 trial of evolocumab and ezetimibe. My doctor tells me that until more is known, I should continue taking the prescribed medicine. Sometimes, however, doctors find it hard to resist reaching into their toolbox for the newest thing that might help. He advised his colleagues not to prescribe Zetia except as a last resort. There should be no danger switching to simvastatin, since it has been shown to be effective at lowering cholesterol and reducing the risk of heart attacks in people with heart disease (Ursoniu et al, Pharmacological Research, online June 9, 2017). I still have muscle pain, cramps and tingling in my legs and feet. Consequently, we expect that other patients might end up taking them. They found that when people dropped ezetimibe their cholesterol rose. Muscle Pain on Zetia: Q. I have tried many statin drugs for cholesterol, but all gave me muscle pain and cramps. The investigators note that many people stopped taking Vytorin or Zetia after they learned about this trial. Q. I have tried many statin drugs for cholesterol, but all gave me muscle pain and cramps. A pharmacist told me that the FDA hasnât recalled it, so it must be all right. In the wake of the ENHANCE study that produced such disappointing results with Vytorin, the American College of Cardiology convened an expert panel to advise their colleagues. The unresolved question is whether they prevent atherosclerosis, heart attacks and strokes. Another reader wrote us shortly after learning of the results of a study that raised questions about ezetimibe: Q. Nearly a decade after the ENHANCE data were reported, cardiologists have taken another look at the value of ezetimibe (Bays et al, Journal of Clinical Lipidology, online May 8, 2017). Dr. said Zetia doesn't typically have the same reaction as statins. BS. In the meantime, keep in mind that Zetia may cause muscle pain itself. Join our daily email newsletter with breaking health news, prescription drug information, home remedies AND you'll get a copy of our brand new full-length health guide â for FREE! Probably the most troublesome side effect patients report on one of these drugs is muscle pain or weakness. There was a lot of hoopla recently about the drug Zetia. Unfortunately, it didnât reduce the risk of dying from cardiovascular causes. Terry is one of the country's leading authorities on the science behind folk remedies. We're empowering you to make wise decisions about your own health, by providing you with essential health information about both medical and alternative treatment options. A. Zetia (ezetimibe) and Vytorin (ezetimibe and simvastatin) lower cholesterol. Is it harmful to switch abruptly to another cholesterol-lowering medicine such as simvastatin? With so many drugs now available to lower cholesterol, people naturally would like to know about the benefits and risks of each. Vytorin lowered bad LDL cholesterol more than Zocor did but this did not lead to healthier arteries. I have problems taking statins. Can you shed any light on this? The study you heard about was called ENHANCE because the company hoped Vytorin would be better than Zocor (simvastatin) alone. Common side effects of ezetimibe include diarrhea, abdominal pain, back pain, joint pain, muscle aches… Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. But what about ezetimibe (Zetia)? Can Zetia cause this? My doctor put me on Zetia and insists it canât cause muscle pain since it is not absorbed into the blood stream. Zetia works by decreasing the absorption of cholesterol from the intestine. It would be appropriate to discuss your treatment with your doctor to see if there is another approach that might suit you better. Zetia helps you reduce bad cholesterol which can assist in stopping serious problems such as heart attack and stroke. Evolocumab (Repatha) and alirocumab (Praluent) are PCSK9 inhibitors. Dysphagia and stomach upset were the two main side effects I experienced with Zetia, at both 5mg and 10mg doses. At this time, these pricey medications are considered appropriate for treating people with familial high cholesterol. We have written quite a bit about the side effects of statins such as atorvastatin (Lipitor), rosuvastatin (Crestor) and simvastatin (Zocor). Terry Graedon, PhD, is a medical anthropologist and co-host of The Peopleâs Pharmacy radio show, co-author of The Peopleâs Pharmacy syndicated newspaper columns and numerous books, and co-founder of The Peopleâs Pharmacy website. He was not the only one to see ezetimibe in a less positive light. Can Zetia cause this? Cardiologist Steven Nissen, MD, of the Cleveland Clinic said he was shocked by the results. Most of the studies about Zetia in which Merck and Schering have published the results covered periods of only 12 weeks not enough time for liver problems to develop in most patients. Although Zetia works differently from statin cholesterol-lowering drugs such as Lipitor or Zocor, it is absorbed into the bloodstream. These thought leaders suggest that doctors should stick with statin-type cholesterol-lowering drugs, which have a proven track record. She is a Fellow of the Society of Applied Anthropology. They lower cholesterol dramatically through a different mechanism from statins. Muscle side effects seem to be less common with Zetia than with the statin drugs, but Zetia may cause muscle problems. About 60 percent of U.S. patients who are taking Zetia now receive the drug as part of Vytorin. Repatha has been shown to reduce the risk of heart attack and stroke (Sabatine et al, New England Journal of Medicine, May 4, 2017). Safeguards Before Taking Zetia. Zetia (ezetimibe) is a lipid-lowering compound used to treat high cholesterol. As it turns out, Zetia may cause muscle problems, too. INFREQUENT side effects Backache Diarrhea Inflammation Of The Tissue Lining The Sinuses Joint Pain Low Energy Muscle Pain Pain In The Arms Or Legs Stomach Cramps The Flu Throat Irritation My doctor put me on Zetia and insists it can’t cause muscle pain since it is not absorbed into the blood stream. Within the past few years, FDA has approved new drugs to lower cholesterol. I called my doctor, who told me to continue taking it, but if itâs not doing anything good for my high cholesterol, why bother? As it turns out, Zetia may cause muscle problems, too. Side effects of Zetia include: diarrhea, back pain, stomach or abdominal pain, numbness or tingly feeling, tired feeling, headache, dizziness, depressed mood, That increased their predicted risk of cardiovascular disease. They do not have data to show whether people who stopped taking Zetia had more heart attacks or strokes, so the jury is still out on that. You can learn more about these medications from our interview with Dr. Steve Nissen about the GAUSS-3 trial of evolocumab and ezetimibe in people who have muscle pain on statins. Was on zetia for approx 4 months. Thatâs too bad, they say. A. But the new two-year trial of 720 patients sheds doubt on whether it makes any sense for people battling cholesterol to take Vytorin versus Zocor alone, experts said. Here are some of the other problems those taking Zetia have faced: allergic reactions including facial and throat swelling which may cause difficulty in breathing or swallowing. 3, 2008). It is Show 1031. Scientists compared the thickness of the lining of the carotid arteries in the neck between people put on Vytorin and those on simvastatin (Kastelein et al, New England Journal of Medicine, Apr. 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